作者
Pearl Behl, Christian Bocti, Richard H Swartz, FuQiang Gao, Demetrios J Sahlas, Krista L Lanctot, David L Streiner, Sandra E Black
发表日期
2007/2/1
期刊
Archives of Neurology
卷号
64
期号
2
页码范围
266-272
出版商
American Medical Association
简介
Objective
To investigate changes in cognition, function, and behavior after 1 year in patients with Alzheimer disease being treated with cholinesterase inhibitors, in relation to the presence or absence of subcortical hyperintensities involving the cholinergic pathways.
Design
One-year prospective cohort study.
Setting
Memory Clinic, Sunnybrook Health Sciences Centre, University of Toronto.
Patients
Ninety patients with possible/probable Alzheimer disease who were being treated with cholinesterase inhibitors at baseline.
Interventions
Yearly standardized neuropsychological testing and brain magnetic resonance imaging (MRI). The Cholinergic Pathways Hyperintensities Scale (CHIPS) was applied to baseline MRIs to rate the severity of subcortical hyperintensities in cholinergic pathways. The consensus-derived Age-Related White Matter Changes (ARWMC) Rating Scale was used as a general measure of white …
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P Behl, C Bocti, RH Swartz, FQ Gao, DJ Sahlas… - Archives of Neurology, 2007