作者
M Moore, J Trill, C Simpson, F Webley, M Radford, L Stanton, T Maishman, A Galanopoulou, A Flower, C Eyles, M Willcox, AD Hay, E Van der Werf, S Gibbons, G Lewith, P Little, G Griffiths
发表日期
2019/8/1
期刊
Clinical Microbiology and Infection
卷号
25
期号
8
页码范围
973-980
出版商
Elsevier
简介
Objectives
The aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI).
Methods
A 2 × 2 factorial placebo controlled randomized trial in primary care. The participants were 382 women aged 18–70 years with symptoms of dysuria, urgency, or frequency of urination and suspected by a clinician to have a lower UTI. The interventions were Uva-ursi extract and/or ibuprofen advice. All women were provided with a delayed or ‘back-up’ prescription for antibiotics. Missing data were imputed using multiple imputation methods (ISRCTN registry: ISRCTN43397016).
Results
An ITT analysis of mean score for frequency symptoms assessed on Days 2–4 found no evidence of a difference between Uva-ursi vs. placebo –0.06 (95 …
学术搜索中的文章
M Moore, J Trill, C Simpson, F Webley, M Radford… - Clinical Microbiology and Infection, 2019