作者
Steven B Chinn, Owen A Darr, John H Owen, Emily Bellile, Jonathan B McHugh, Matthew E Spector, Silvana M Papagerakis, Douglas B Chepeha, Carol R Bradford, Thomas E Carey, Mark EP Prince
发表日期
2015/3
期刊
Head & neck
卷号
37
期号
3
页码范围
317-326
简介
Background
Cancer stem cells (CSCs) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain.
Methods
Wound healing and an orthotopic animal model were used to study cells expressing the CSC phenotype (CD44high and aldehyde dehydrogenase [ALDH]+) and assess mobility, tumorigenesis, and metastasis. A prospective collection of 40 patient‐derived primary HNSCC specimens were analyzed for CSC‐proportion compared to clinical variables.
Results
CSCs exhibited significantly faster wound closure and greater tumorigenesis and regional metastasis in vivo than non‐CSCs. In primary patient tumors, size and advanced stage were correlated with elevated proportion of CSCs, however, not with survival.
Conclusion
HNSCC stem cells mediate tumorigenesis and regional …
学术搜索中的文章
SB Chinn, OA Darr, JH Owen, E Bellile, JB McHugh… - Head & neck, 2015