作者
Mike Stembridge, Philip N Ainslie, Lindsey M Boulet, James Anholm, Prajan Subedi, Michael M Tymko, Christopher K Willie, Stephen‐Mark Cooper, Rob Shave
发表日期
2019/2
期刊
The Journal of physiology
卷号
597
期号
4
页码范围
1059-1072
简介
Key points
- We sought to determine the isolated and combined influence of hypovolaemia and hypoxic pulmonary vasoconstriction on the decrease in left ventricular (LV) function and maximal exercise capacity observed under hypobaric hypoxia.
- We performed echocardiography and maximal exercise tests at sea level (344 m), and following 5–10 days at the Barcroft Laboratory (3800 m; White Mountain, California) with and without (i) plasma volume expansion to sea level values and (ii) administration of the pulmonary vasodilatator sildenafil in a double‐blinded and placebo‐controlled trial.
- The high altitude‐induced reduction in LV filling and ejection was abolished by plasma volume expansion but to a lesser extent by sildenafil administration; however, neither intervention had a positive effect on maximal exercise capacity.
- Both hypovolaemia and hypoxic pulmonary vasoconstriction play a role in the reduction of …
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M Stembridge, PN Ainslie, LM Boulet, J Anholm… - The Journal of physiology, 2019