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Radiation therapy is infrequently used in the treatment of advanced ovarian cancer due to the propensity for peritoneal spread and the dose limitations of large field techniques. However, for patients with limited sites of recurrence, advanced radiation techniques such as Stereotactic Body Radiation Therapy (SBRT) may offer an effective treatment option. There are many clinical trials supporting the safety and efficacy of SBRT for lung and liver tumors, but the role for abdominopelvic targets adjacent to gastrointestinal mucosa remains largely investigational, especially in this often heavily pretreated patient population.

A single institution Phase I dose escalation study was conducted to determine the maximum tolerated dose (MTD) of SBRT for patients with limited (≤ 3 sites) abdominopelvic recurrences of ovarian cancer. We utilized a 3+3 design with 3 dose levels: 8 Gy x 3 …