作者
Aaron Ettenberg, Hugh O Pettit, Floyd E Bloom, George F Koob
发表日期
1982/11
期刊
Psychopharmacology
卷号
78
页码范围
204-209
出版商
Springer-Verlag
简介
The hypothesis that separate neural systems mediate the reinforcing properties of opiate and psychomotor stimulant drugs was tested in rats trained to lever-press for IV injections of either cocaine or heroin during daily 3-h sessions. Pretreatment with the opiate receptor antagonist drug naltrexone produced dose-dependent increases in heroin self-administration, but had no effect on the rate or pattern of cocaine self-administration. Similarly, pretreatment with low doses of the dopamine antagonist drug alpha-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration. High doses of alpha-flupenthixol eliminated all responding for cocaine and slightly reduced heroin self-administration. The specificity with which the two antagonist drugs exerted their behavioral effects strongly suggests that independent neural substrates are responsible for the reinforcing actions of heroind …
引用总数
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A Ettenberg, HO Pettit, FE Bloom, GF Koob - Psychopharmacology, 1982