作者
Jon C Horvitz, Aaron Ettenberg
发表日期
1988/12/1
期刊
Pharmacology Biochemistry and Behavior
卷号
31
期号
4
页码范围
861-865
出版商
Elsevier
简介
To test the hypothesis that dopamine antagonist drugs attenuate the reinforcing properties of foods, rats previously trained to traverse a straight runway for food reward subsequently underwent extinction sessions. After running speeds had substantially decreased, rats received a single food-rewarded trial either in the presence or absence of haloperidol (0, 0.15 or 0.30 mg/kg IP). Twenty-four hours later, animals were tested for reinstatement of the running response during a drug-free test trial. Animals that were nondrugged during the food-rewarded trial showed increases in running speed on the test trial relative to extinction baseline speeds. In contrast, animals under the influence of haloperidol during the food-rewarded trial failed to show test day increases in running speed. Additional control groups ruled out the possibility that the haloperidol results were due to either motor or state-dependent learning effects …
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