作者
Natalia Lago, Fernanda N Kaufmann, María Luciana Negro-Demontel, Daniela Alí-Ruiz, Gabriele Ghisleni, Natalia Rego, Andrea Arcas-García, Nathalia Vitureira, Karen Jansen, Luciano M Souza, Ricardo A Silva, Diogo R Lara, Bruno Pannunzio, Juan Andrés Abin-Carriquiry, Jesús Amo-Aparicio, Celia Martin-Otal, Hugo Naya, Dorian B McGavern, Joan Sayós, Rubèn López-Vales, Manuella P Kaster, Hugo Peluffo
发表日期
2020/3/24
期刊
Proceedings of the National Academy of Sciences
卷号
117
期号
12
页码范围
6651-6662
出版商
National Academy of Sciences
简介
A role for microglia in neuropsychiatric diseases, including major depressive disorder (MDD), has been postulated. Regulation of microglial phenotype by immune receptors has become a central topic in many neurological conditions. We explored preclinical and clinical evidence for the role of the CD300f immune receptor in the fine regulation of microglial phenotype and its contribution to MDD. We found that a prevalent nonsynonymous single-nucleotide polymorphism (C/T, rs2034310) of the human CD300f receptor cytoplasmic tail inhibits the protein kinase C phosphorylation of a threonine and is associated with protection against MDD, mainly in women. Interestingly, CD300f−/− mice displayed several characteristic MDD traits such as augmented microglial numbers, increased interleukin 6 and interleukin 1 receptor antagonist messenger RNA, alterations in synaptic strength, and noradrenaline-dependent and …
学术搜索中的文章
N Lago, FN Kaufmann, ML Negro-Demontel, D Alí-Ruiz… - Proceedings of the National Academy of Sciences, 2020