作者
Maja V Maraldo, Francesco Giusti, Ivan R Vogelius, Michael Lundemann, Marleen AE van der Kaaij, Safaa Ramadan, Bart Meulemans, Michel Henry-Amar, Berthe MP Aleman, John Raemaekers, Paul Meijnders, Elisabeth C Moser, Hanneke C Kluin-Nelemans, Pierre Feugier, Olivier Casasnovas, Catherine Fortpied, Lena Specht
发表日期
2015/11/1
期刊
The Lancet Haematology
卷号
2
期号
11
页码范围
e492-e502
出版商
Elsevier
简介
Background
Cardiovascular disease after treatment is an important concern in cancer survivors. However, knowledge of cardiotoxicity is limited by the retrospective nature of data, which often does not contain details of treatment exposure. To facilitate individual risk counselling of patients, we aimed to quantify the effect of anthracyclines, vinca-alkaloids, and radiotherapy on the risk of cardiovascular disease in patients treated for Hodgkin's lymphoma.
Methods
In 2009–10, a Life Situation Questionnaire (LSQ) was distributed to patients by mail to assess late-onset effects of Hodgkin's lymphoma treatment in patients who were included in nine successive European Organisation for Research and Treatment of Cancer (EORTC) and the Groupe d'Etude des Lymphomes de l'Adulte (GELA, now renamed LYSA) randomised trials between 1964 and 2004. We reconstructed the mean radiation doses to the heart and carotid …
学术搜索中的文章
MV Maraldo, F Giusti, IR Vogelius, M Lundemann… - The Lancet Haematology, 2015