作者
Marleen AE van Der Kaaij, Natacha Heutte, Paul Meijnders, Edwige Abeilard-Lemoisson, Michele Spina, Lotte C Moser, Anouk Allgeier, Bart Meulemans, Brice Dubois, Arnold HM Simons, Pieternella J Lugtenburg, Berthe MP Aleman, Evert M Noordijk, Christophe Fermé, José Thomas, Aspasia Stamatoullas, Christophe Fruchart, Pauline Brice, Isabelle Gaillard, Jeanette K Doorduijn, Catherine Sebban, Wilma GJM Smit, Serge Bologna, Judith M Roesink, Francisca Ong, Marc PE André, John MM Raemaekers, Michel Henry-Amar, Hanneke C Kluin-Nelemans
发表日期
2012/11/1
期刊
Journal of clinical oncology
卷号
30
期号
31
页码范围
3854-3863
出版商
American Society of Clinical Oncology
简介
Purpose
We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls.
Patients and Methods
A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood.
Results
In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years …
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MAE van Der Kaaij, N Heutte, P Meijnders… - Journal of clinical oncology, 2012