作者
Gregory J Grosicki, Brittany B Barrett, Davis A Englund, C Liu, Thomas G Travison, Tommy Cederholm, Afsaneh Koochek, Åsa von Berens, Thomas Gustafsson, T Benard, KF Reid, RA Fielding
发表日期
2020/1
期刊
The Journal of frailty & aging
卷号
9
页码范围
57-63
出版商
Springer International Publishing
简介
Background
Human aging is characterized by a chronic, low-grade inflammation suspected to contribute to reductions in skeletal muscle size, strength, and function. Inflammatory cytokines, such as interleukin-6 (IL-6), may play a role in the reduced skeletal muscle adaptive response seen in older individuals.
Objectives
To investigate relationships between circulating IL-6, skeletal muscle health and exercise adaptation in mobility-limited older adults.
Design
Randomized controlled trial.
Setting
Exercise laboratory on the Health Sciences campus of an urban university.
Participants
99 mobility-limited (Short Physical Performance Battery (SPPB) ≤9) older adults.
Intervention
6-month structured physical activity with or without a protein and vitamin D nutritional supplement.
Measurements
Circulating IL-6, skeletal muscle size, composition (percent normal density muscle tissue), strength, power, and specific …
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GJ Grosicki, BB Barrett, DA Englund, C Liu… - The Journal of frailty & aging, 2020