作者
Edward S Chambers, Alexander Viardot, Arianna Psichas, Douglas J Morrison, Kevin G Murphy, Sagen EK Zac-Varghese, Kenneth MacDougall, Tom Preston, Catriona Tedford, Graham S Finlayson, John E Blundell, Jimmy D Bell, E Louise Thomas, Shahrul Mt-Isa, Deborah Ashby, Glen R Gibson, Sofia Kolida, Waljit S Dhillo, Stephen R Bloom, Wayne Morley, Stuart Clegg, Gary Frost
发表日期
2015/11/1
期刊
Gut
卷号
64
期号
11
页码范围
1744-1754
出版商
BMJ Publishing Group
简介
Objective
The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.
Design
To investigate whether propionate promotes PYY and GLP-1 secretion, a primary cultured human colonic cell model was developed. To deliver propionate specifically to the colon, we developed a novel inulin-propionate ester. An acute randomised, controlled cross-over study was used to assess the effects of this inulin-propionate ester on energy intake and plasma PYY and GLP-1 concentrations. The long-term effects of inulin-propionate ester on weight gain were subsequently assessed in a …
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ES Chambers, A Viardot, A Psichas, DJ Morrison… - Gut, 2015
