作者
Philip SJ Weston, William Coath, Matthew J Harris, Ian B Malone, John Dickson, Franklin I Aigbirhio, David M Cash, Hui Zhang, Jonathan M Schott
发表日期
2023/6
期刊
Alzheimer's & Dementia
卷号
19
期号
6
页码范围
2750-2754
简介
Introduction
In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain.
Methods
We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed.
Results
When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R2 = 0.56, p = 0.008) and between orientation dispersion and tau (partial R2 = 0.66, p = 0.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R2 = 0.43, p = 0.030), but not between …
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PSJ Weston, W Coath, MJ Harris, IB Malone, J Dickson… - Alzheimer's & Dementia, 2023