作者
Ivanna M Pavisic, Kirsty Lu, Sarah E Keuss, Sarah-Naomi James, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Heidi Murray-Smith, David M Cash, William Coath, Andrew Wong, Nick C Fox, Sebastian J Crutch, Marcus Richards, Jonathan M Schott
发表日期
2021/11/1
期刊
Journal of Neurology, Neurosurgery & Psychiatry
卷号
92
期号
11
页码范围
1215-1221
出版商
BMJ Publishing Group Ltd
简介
Objective
To investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study.
Methods
Cognitively unimpaired ~70-year-old participants, all born in the same week in 1946 (n=460, 49% female, 18% amyloid-positive), underwent assessments including the SCD-Questionnaire (MyCog). MyCog scores were evaluated with respect to 18F-Florbetapir-PET amyloid status (positive/negative). Associations with anxiety, depression, objective cognition (measured by the Preclinical Alzheimer Cognitive Composite, PACC) and family history of dementia were also investigated. The informant’s perspective on SCD was evaluated in relation to MyCog score.
Results
Anxiety (mean (SD) trait anxiety score: 4.4 (3.9)) was associated with higher MyCog scores, especially in women. MyCog …
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IM Pavisic, K Lu, SE Keuss, SN James, CA Lane… - Journal of Neurology, Neurosurgery & Psychiatry, 2021