作者
Christopher A Lane, Josephine Barnes, Jennifer M Nicholas, Carole H Sudre, David M Cash, Ian B Malone, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Kirsty Lu, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Marcus Richards, Nick C Fox, Jonathan M Schott
发表日期
2020/2/1
期刊
JAMA neurology
卷号
77
期号
2
页码范围
175-183
出版商
American Medical Association
简介
Importance
Midlife vascular risk burden is associated with late-life dementia. Less is known about if and how risk exposure in early adulthood influences late-life brain health.
Objective
To determine the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and pathology using measures of white matter–hyperintensity volume, β-amyloid load, and whole-brain and hippocampal volumes.
Design, Setting, and Participants
This prospective longitudinal cohort study, Insight 46, is part of the Medical Research Council National Survey of Health and Development, which commenced in 1946. Participants had vascular risk factors evaluated at ages 36 years (early adulthood), 53 years (midlife), and 69 years (early late life). Participants were assessed with multimodal magnetic resonance imaging and florbetapir-amyloid positron emission tomography scans between May 2015 …
学术搜索中的文章
CA Lane, J Barnes, JM Nicholas, CH Sudre, DM Cash… - JAMA neurology, 2020