作者
Kirsty Lu, Jennifer M Nicholas, Sarah‐Naomi James, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah E Keuss, Sarah M Buchanan, Heidi Murray‐Smith, David M Cash, Carole H Sudre, Ian B Malone, William Coath, Andrew Wong, Susie MD Henley, Nick C Fox, Marcus Richards, Jonathan M Schott, Sebastian J Crutch
发表日期
2020
期刊
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
卷号
12
期号
1
页码范围
e12076
简介
Introduction
We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.
Methods
Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2‐choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra‐individual variability in RT) and life‐course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ‐positivity.
Results
Cognitively normal Aβ‐positive participants had 10% more variable RTs than Aβ‐negative participants, despite having similar mean RTs. Childhood cognitive ability and education …
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K Lu, JM Nicholas, SN James, CA Lane, TD Parker… - Alzheimer's & Dementia: Diagnosis, Assessment & …, 2020