作者
Kirsty Lu, Jennifer M Nicholas, Jessica D Collins, Sarah-Naomi James, Thomas D Parker, Christopher A Lane, Ashvini Keshavan, Sarah E Keuss, Sarah M Buchanan, Heidi Murray-Smith, David M Cash, Carole H Sudre, Ian B Malone, William Coath, Andrew Wong, Susie MD Henley, Sebastian J Crutch, Nick C Fox, Marcus Richards, Jonathan M Schott
发表日期
2019/12/3
期刊
Neurology
卷号
93
期号
23
页码范围
e2144-e2156
出版商
Lippincott Williams & Wilkins
简介
Objective
To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a substudy of the Medical Research Council National Survey of Health and Development.
Methods
A total of 502 individuals born in the same week in 1946 underwent cognitive assessment at age 69–71 years, including an adapted version of the PACC and a test of nonverbal reasoning. Performance was characterized with respect to sex, childhood cognitive ability, education, and socioeconomic position (SEP). In a subsample of 406 cognitively normal participants, associations were investigated between cognition and β-amyloid (Aβ) positivity (determined from Aβ-PET imaging), whole brain volumes, white matter hyperintensity volumes (WMHV), and APOE ε4.
Results
Childhood …
学术搜索中的文章
K Lu, JM Nicholas, JD Collins, SN James, TD Parker… - Neurology, 2019