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In the last years, responsive hydrogels have been widely studied due to their capacity to interact with the biological environment in a pre-programmed manner. Another aspect worth considering when synthesizing intelligent hydrogels is the introduction of self – healing characteristics, which can sustain the recovery of a material to its original shape.

The study was developed as an extension of an ongoing investigation regarding new interpenetrated gels (IPNs) based on poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) and poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane) (PITAU) and it was focused on highlighting not only the rheological properties and the behaviour in simulated biological fluids, but also to confirm the possibility of using this kind of hydrogel as a drug delivery system. The semi-IPN structure was achieved by crosslinking DMAEMA into a preformed network of …