作者
Mohammad L Rahman, Linda Valeri, Molly L Kile, Maitreyi Mazumdar, Golam Mostofa, Qazi Qamruzzaman, Mahmudur Rahman, Andrea Baccarelli, Liming Liang, Russ Hauser, David C Christiani
发表日期
2017/11/1
期刊
Environment international
卷号
108
页码范围
32-40
出版商
Pergamon
简介
Background
Shortening of gestation and intrauterine growth restriction (IUGR) are the two main determinants of birthweight. Low birthweight has been linked with prenatal arsenic exposure, but the causal relation between arsenic and birthweight is not well understood.
Objectives
We applied a quantile causal mediation analysis approach to determine the association between prenatal arsenic exposure and birthweight in relation to shortening of gestation and IUGR, and whether the susceptibility of arsenic exposure varies by infant birth sizes.
Methods
In a longitudinal birth cohort in Bangladesh, we measured arsenic in drinking water (n = 1182) collected at enrollment and maternal toenails (n = 1104) collected ≤ 1-month postpartum using inductively coupled plasma mass spectrometry. Gestational age was determined using ultrasound at ≤ 16 weeks' gestation. Demographic information was collected using a …
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