作者
Christian C Abnet, Neal D Freedman, Nan Hu, Zhaoming Wang, Kai Yu, Xiao-Ou Shu, Jian-Min Yuan, Wei Zheng, Sanford M Dawsey, Linda M Dong, Maxwell P Lee, Ti Ding, You-Lin Qiao, Yu-Tang Gao, Woon-Puay Koh, Yong-Bing Xiang, Ze-Zhong Tang, Jin-Hu Fan, Chaoyu Wang, William Wheeler, Mitchell H Gail, Meredith Yeager, Jeff Yuenger, Amy Hutchinson, Kevin B Jacobs, Carol A Giffen, Laurie Burdett, Joseph F Fraumeni Jr, Margaret A Tucker, Wong-Ho Chow, Alisa M Goldstein, Stephen J Chanock, Philip R Taylor
发表日期
2010/9
期刊
Nature genetics
卷号
42
期号
9
页码范围
764-767
出版商
Nature Publishing Group US
简介
We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 × 10−9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 × 10−9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 × 10−15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide …
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CC Abnet, ND Freedman, N Hu, Z Wang, K Yu, XO Shu… - Nature genetics, 2010