作者
Veronica Wendy Setiawan, Hannah P Yang, Malcolm C Pike, Susan E McCann, Herbert Yu, Yong-Bing Xiang, Alicja Wolk, Nicolas Wentzensen, Noel S Weiss, Penelope M Webb, Piet A Van Den Brandt, Koen Van De Vijver, Pamela J Thompson, Australian National Endometrial Cancer Study Group, Brian L Strom, Amanda B Spurdle, Robert A Soslow, Xiao-ou Shu, Catherine Schairer, Carlotta Sacerdote, Thomas E Rohan, Kim Robien, Harvey A Risch, Fulvio Ricceri, Timothy R Rebbeck, Radhai Rastogi, Jennifer Prescott, Silvia Polidoro, Yikyung Park, Sara H Olson, Kirsten B Moysich, Anthony B Miller, Marjorie L McCullough, Rayna K Matsuno, Anthony M Magliocco, Galina Lurie, Lingeng Lu, Jolanta Lissowska, Xiaolin Liang, James V Lacey Jr, Laurence N Kolonel, Brian E Henderson, Susan E Hankinson, Niclas Håkansson, Marc T Goodman, Mia M Gaudet, Montserrat Garcia-Closas, Christine M Friedenreich, Jo L Freudenheim, Jennifer Doherty, Immaculata De Vivo, Kerry S Courneya, Linda S Cook, Chu Chen, James R Cerhan, Hui Cai, Louise A Brinton, Leslie Bernstein, Kristin E Anderson, Hoda Anton-Culver, Leo J Schouten, Pamela L Horn-Ross
发表日期
2013/7/10
来源
Journal of Clinical Oncology
卷号
31
期号
20
页码范围
2607-2618
出版商
American Society of Clinical Oncology
简介
Purpose
Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors.
Patients and Methods
Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors.
Results
Parity, oral …
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VW Setiawan, HP Yang, MC Pike, SE McCann, H Yu… - Journal of Clinical Oncology, 2013