作者
Veronica N Kos, Christopher A Desjardins, Allison Griggs, Gustavo Cerqueira, Andries Van Tonder, Matthew TG Holden, Paul Godfrey, Kelli L Palmer, Kip Bodi, Emmanuel F Mongodin, Jennifer Wortman, Michael Feldgarden, Trevor Lawley, Steven R Gill, Brian J Haas, Bruce Birren, Michael S Gilmore
发表日期
2012/7/2
期刊
MBio
卷号
3
期号
3
页码范围
10.1128/mbio. 00112-12
出版商
American Society for Microbiology
简介
Methicillin-resistant Staphylococcus aureus (MRSA) strains are leading causes of hospital-acquired infections in the United States, and clonal cluster 5 (CC5) is the predominant lineage responsible for these infections. Since 2002, there have been 12 cases of vancomycin-resistant S. aureus (VRSA) infection in the United States—all CC5 strains. To understand this genetic background and what distinguishes it from other lineages, we generated and analyzed high-quality draft genome sequences for all available VRSA strains. Sequence comparisons show unambiguously that each strain independently acquired Tn1546 and that all VRSA strains last shared a common ancestor over 50 years ago, well before the occurrence of vancomycin resistance in this species. In contrast to existing hypotheses on what predisposes this lineage to acquire Tn1546, the barrier posed by restriction systems appears to be intact in …
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VN Kos, CA Desjardins, A Griggs, G Cerqueira… - MBio, 2012