作者
Arnaud Capron, Michel Mourad, Martine De Meyer, Luc De Pauw, Djamila Chaib Eddour, Dominique Latinne, Laure Elens, Vincent Haufroid, Pierre Wallemacq
发表日期
2010/5/1
期刊
Pharmacogenomics
卷号
11
期号
5
页码范围
703-714
出版商
Taylor & Francis
简介
Aims
This prospective study investigated the effect of genetic polymorphisms in a biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) whole blood concentrations in renal transplantation, and more specifically on peripheral blood mononuclear cell (PBMC) drug concentrations, after renal transplantation. Materials & methods
A total of 96 renal transplant recipients were genotyped for the exon 11 (1199G>A), 21 (3435C>T) and 26 (2677G>T/A) polymorphisms in the ABCB1 gene and for the intron 3 polymorphism in the CYP3A5 gene. Tac blood and PBMC concentrations were determined at day 7 after transplantation and at steady state, and then compared with recipient genotypes. Results & conclusion
The ABCB1 1199G>A, 3435C>T and 2677G>T/A SNPs, appeared to reduce the activity of P-glycoprotein towards Tac, increasing Tac PBMC concentrations. The impact of …学术搜索中的文章
A Capron, M Mourad, M De Meyer, L De Pauw… - Pharmacogenomics, 2010