作者
Pavel Vodicka, Rajiv Kumar, Rudolf Stetina, Somali Sanyal, Pavel Soucek, Vincent Haufroid, Maria Dusinska, Miroslava Kuricova, Maria Zamecnikova, Ludovit Musak, Jana Buchancova, Hannu Norppa, Ari Hirvonen, Ludmila Vodickova, Alessio Naccarati, Zora Matousu, Kari Hemminki
发表日期
2004/5/1
期刊
Carcinogenesis
卷号
25
期号
5
页码范围
757-763
出版商
Oxford University Press
简介
We analysed the associations between genetic polymorphisms in genes coding for DNA repair enzymes XPD (exon 23 A → C, K751Q), XPG (exon 15 G → C, D1104H), XPC (exon 15 A → C, K939Q), XRCC1 (exon 10 G → A, R399Q) and XRCC3 (exon 7 C → T, T241 M) and the levels of chromosomal aberrations (CAs) and single-strand breaks (SSBs) in peripheral lymphocytes in a central European population. We also measured the irradiation-specific DNA repair rates and the repair rates of 8-oxoguanines in these individuals. An elevated frequency of CAs was observed in individuals with the XPD exon 23 A allele ( AA and AC ) genotypes ( F = 3.6, P = 0.028, ANOVA). In multifactorial analysis of variance, the XPD exon 23 …
引用总数
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