作者
Miia Kivipelto, Eeva-Liisa Helkala, Mikko P Laakso, Tuomo Hänninen, Merja Hallikainen, Kari Alhainen, Susan Iivonen, Arto Mannermaa, Jaakko Tuomilehto, Aulikki Nissinen, Hilkka Soininen
发表日期
2002/8/6
期刊
Annals of internal medicine
卷号
137
期号
3
页码范围
149-155
出版商
American College of Physicians
简介
Background
Presence of the apolipoprotein E (apoE) ε4 allele, which is involved in cholesterol metabolism, is the most important genetic risk factor for Alzheimer disease. Elevated midlife values for total cholesterol level and blood pressure have been implicated recently as risk factors for Alzheimer disease.
Objective
To study the relative importance and the putative relationship among the apoE ε4 allele, midlife total cholesterol level, and midlife blood pressure as risk factors for late-life Alzheimer disease.
Design
Prospective population-based study.
Setting
Kuopio and Joensuu, eastern Finland.
Participants
Participants were derived from random population surveys from 1972, 1977, 1982, and 1987. A total of 1449 persons (73%), 65 to 79 years of age, participated in the …
引用总数
学术搜索中的文章
M Kivipelto, EL Helkala, MP Laakso, T Hänninen… - Annals of internal medicine, 2002
M Kivipelto, MP Laakso, T Hanninen, M Hallikainen… - NEUROBIOLOGY OF AGING, 2002
M Kivipelto, EL Helkala, MP Laakso, T Hänninen - Ann Intern Med, 2002