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The stress parents feel in their parenting roles and the ways they relate to themselves in difficult or distressing situations, such as with self-compassion, are influenced by their attachment orientations and may account for the well-known association between the quality of parents’ attachment to their own parents and their children’s developmental outcomes. We explored the association between self-compassion and parenting stress and their mediating role in the link between mothers’ attachment orientations and children’s quality of life (QoL). A total of 171 family dyads composed of a child/adolescent aged 8–18 years and the child’s mother participated in the study. Mothers completed self-report measures of attachment toward their own mother (ECR-RS), self-compassion (SELFCS), and parenting stress (PSI). The children completed a measure of QoL (KIDSCREEN-10). The current study showed that …