作者
Salvatore Santo Signorelli, Sergio Neri, Salvatore Sciacchitano, Luigi Di Pino, Maria Pia Costa, Giuseppe Pennisi, Dario Ierna, Sarina Caschetto
发表日期
2001/7/25
期刊
Maturitas
卷号
39
期号
1
页码范围
39-42
出版商
Elsevier
简介
Aim
our study assessed whether minor or major hormonal deficiency influenced oxidative status and vascular wall structure in menopausal women.
Methods
the study series was made up of 62 non hypertensive non diabetic menopausal women (mean age 52.3±4.7 years) divided into two groups depending on duration of menopause (group 1 duration 0–5 years; group 2 duration over 5 years). Total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), malondialdehyde (MDA) and common carotid artery wall intima-media thickness (IMT) were determined in the entire series.
Results
mean TC, LDL-C, TG, MDA and IMT values were higher in group 2 than group 1. The intergroup difference between MDA (P<0.007) and IMT values (P<0.006) values was statistically significant.
Conclusions
the study revealed a close temporal correlation between plasma oxidative stress and carotid …
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S Santo Signorelli, S Neri, S Sciacchitano, L Di Pino… - Maturitas, 2001