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Methods:

Thirty-two IBD patients without cardiovascular risk factors and 32 matched controls were enrolled (age 19–49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used to measure carotid–femoral and carotid–radial (muscular artery) pulse wave velocity (PWV), augmentation index and central blood pressure.

Results:

Carotid–femoral PWV was higher in IBD patients than in controls (6.6±1.4 vs. 6.0±0.8 m/s, respectively, P< 0.05), as well as carotid–radial PWV (8.5±1.2 vs. 7.2±1.0 m/s, P< 0.001). Central pulse pressure was higher in IBD than in controls (32±6 vs. 28±7 mmHg, P< 0.05). Aging was an important determinant of carotid–femoral PWV in both groups and carotid–radial PWV only in IBD patients. In fully adjusted model performed in both groups of patients considered as a whole, age was positively associated with carotid–femoral PWV [R 2= 0.10;+ 0.05 m/s per 1 year of aging, 95 …