作者
Richard A Gibbs, George M Weinstock, Michael L Metzker, Donna M Muzny, Erica J Sodergren, Steven Scherer, Graham Scott, David Steffen, Kim C Worley, Paula E Burch, Geoffrey Okwuonu, Sandra Hines, Lora Lewis, Christine DeRamo, Oliver Delgado, Shannon Dugan-Rocha, George Miner, Margaret Morgan, Alicia Hawes, Rachel Gill, Robert A Holt, Mark D Adams, Peter G Amanatides, Holly Baden-Tillson, Mary Barnstead, Soo Chin, Cheryl A Evans, Steve Ferriera, Carl Fosler, Anna Glodek, Zhiping Gu, Don Jennings, Cheryl L Kraft, Trixie Nguyen, Cynthia M Pfannkoch, Cynthia Sitter, Granger G Sutton, J Craig Venter, Trevor Woodage, Douglas Smith, Hong-Mei Lee, Erik Gustafson, Patrick Cahill, Arnold Kana, Lynn Doucette-Stamm, Keith Weinstock, Kim Fechtel, Robert B Weiss, Diane M Dunn, Eric D Green, Robert W Blakesley, Gerard G Bouffard, Pieter J De Jong, Kazutoyo Osoegawa, Baoli Zhu, Marco Marra, Jacqueline Schein, Ian Bosdet, Chris Fjell, Steven Jones, Martin Krzywinski, Carrie Mathewson, Asim Siddiqui, Natasja Wye, John McPherson, Shaying Zhao, Claire M Fraser, Jyoti Shetty, Sofiya Shatsman, Keita Geer, Yixin Chen, Sofyia Abramzon, William C Nierman, Paul H Havlak, Rui Chen, K James Durbin, Amy Egan, Yanru Ren, Xing-Zhi Song, Bingshan Li, Yue Liu, Xiang Qin, Simon Cawley, AJ Cooney, Lisa M D'Souza, Kirt Martin, Jia Qian Wu, Manuel L Gonzalez-Garay, Andrew R Jackson, Kenneth J Kalafus, Michael P McLeod, Aleksandar Milosavljevic, Davinder Virk, Andrei Volkov, David A Wheeler, Zhengdong Zhang, Jeffrey A Bailey, Evan E Eichler, Eray Tuzun, Ewan Birney, Emmanuel Mongin, Abel Ureta-Vidal, Cara Woodwark, Evgeny Zdobnov, Peer Bork, Mikita Suyama, David Torrents, Marina Alexandersson, Barbara J Trask, Janet M Young, Hui Huang, Huajun Wang, Heming Xing, Sue Daniels, Darryl Gietzen, Jeanette Schmidt, Kristian Stevens, Ursula Vitt, Jim Wingrove, Francisco Camara, M Mar Albà, Josep F Abril, Roderic Guigo, Arian Smit, Inna Dubchak, Edward M Rubin, Olivier Couronne, Alexander Poliakov, Norbert Hübner, Detlev Ganten, Claudia Goesele, Oliver Hummel, Thomas Kreitler, Young-Ae Lee, Jan Monti, Herbert Schulz, Heike Zimdahl, Heinz Himmelbauer, Hans Lehrach, Howard J Jacob, Susan Bromberg, Jo Gullings-Handley, Michael I Jensen-Seaman, Anne E Kwitek, Jozef Lazar, Dean Pasko, Peter J Tonellato, Simon Twigger, Chris P Ponting, Jose M Duarte
发表日期
2004/4/1
期刊
Nature
卷号
428
期号
6982
页码范围
493-521
出版商
Nature Publishing Group
简介
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality ‘draft’ covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events …
引用总数
学术搜索中的文章
University of Utah Weiss Robert B. 14 Dunn Diane M … - Nature, 2004
