作者
Janine Bilsborough, Donald YM Leung, Mark Maurer, Michael Howell, Mark Boguniewcz, Lena Yao, Harold Storey, Cosette LeCiel, Brandon Harder, Jane A Gross
发表日期
2006/2/1
期刊
Journal of Allergy and Clinical Immunology
卷号
117
期号
2
页码范围
418-425
出版商
Mosby
简介
BACKGROUND
IL-31 is a newly discovered T-cell cytokine that, when overexpressed in mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD).
OBJECTIVE
We sought to investigate the expression of IL-31 and IL-31 receptor A (IL-31RA) in skin biopsy specimens and peripheral blood cells from patients with AD and healthy individuals.
METHODS
Expression of IL-31 and IL-31RA was evaluated in skin biopsy specimens from patients with AD and healthy individuals by means of immunohistochemistry and RT-PCR. IL-31 protein production by skin-homing cutaneous lymphocyte antigen (CLA)–positive T cells was also assessed.
RESULTS
IL-31RA protein was expressed by keratinocytes and infiltrating macrophages in skin biopsy specimens from patients with AD. Comparisons between skin from patients with AD and healthy skin showed IL-31RA expression at higher levels on …
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