作者
Ellen Boswijk, Karin JC Sanders, Evie PM Broeders, Marlies de Ligt, Guy HEJ Vijgen, Bas Havekes, Alma MA Mingels, Roel Wierts, Wouter D van Marken Lichtenbelt, Patrick Schrauwen, Felix M Mottaghy, Joachim E Wildberger, Jan Bucerius
发表日期
2019/7/1
期刊
European journal of nuclear medicine and molecular imaging
卷号
46
页码范围
1428-1438
出版商
Springer Berlin Heidelberg
简介
Purpose
We aimed to investigate the influence of both hypothyroidism and thyroid-stimulating hormone (TSH) suppression on vascular inflammation, as assessed with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT).
Methods
Ten thyroid carcinoma patients underwent an 18F-FDG PET/CT during post-thyroidectomy hypothyroidism and during thyrotropin (TSH) suppression after 131I (radioiodine) ablation therapy. We analysed the 18F-FDG uptake in the carotids, aortic arch, ascending, descending, and abdominal aorta to investigate the effects of thyroid hormone status on arterial inflammation. Target-to-background ratios (TBRs) corrected for blood pool activity were established for all arterial territories. Results were further compared to euthyroid historic control subjects …
学术搜索中的文章
TSH suppression aggravates arterial inflammation—an 18 F-FDG PET study in thyroid carcinoma patients
E Boswijk, KJC Sanders, EPM Broeders, M de Ligt… - European journal of nuclear medicine and molecular …, 2019