作者
Susan M Landau, Mark A Mintun, Abhinay D Joshi, Robert A Koeppe, Ronald C Petersen, Paul S Aisen, Michael W Weiner, William J Jagust, Alzheimer's Disease Neuroimaging Initiative
发表日期
2012/10
期刊
Annals of neurology
卷号
72
期号
4
页码范围
578-586
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) population, we examined (1) cross‐sectional relationships between amyloid deposition, hypometabolism, and cognition, and (2) associations between amyloid and hypometabolism measurements and longitudinal cognitive measurements.
Methods
We examined associations between mean cortical florbetapir uptake, mean 18F‐fluorodeoxyglucose–positron emission tomography (FDG‐PET) within a set of predefined regions, and Alzhiemer's Disease Assessment Scale (ADAS‐cog) performance in 426 ADNI participants (126 normal, 162 early mild cognitive impairment [EMCI], 85 late MCI [LMCI], 53 Alzheimer disease [AD] patients). For a subset of these (76 normal, 81 LMCI) we determined whether florbetapir and FDG‐PET were associated with retrospective decline in longitudinal ADAS‐cog measurements.
Results
Twenty …
学术搜索中的文章
SM Landau, MA Mintun, AD Joshi, RA Koeppe… - Annals of neurology, 2012