作者
John Horton, C Witt, Eric A Ottesen, Janis K Lazdins, David G Addiss, Kwablah Awadzi, Michael J Beach, Vicente Y Belizario, Samuel K Dunyo, Marcos Espinel, John O Gyapong, M Hossain, MM Ismail, RL Jayakody, Patrick J Lammie, William Makunde, D Richard-Lenoble, Billy Selve, R Krishna Shenoy, Paul E Simonsen, C Njeri Wamae, Mirani V Weerasooriya
发表日期
2000/10
来源
Parasitology
卷号
121
期号
S1
页码范围
S147-S160
出版商
Cambridge University Press
简介
This review of the safety of the co-administration regimens to be used in programmes to eliminate lymphatic filariasis (albendazole+ivermectin or albendazole+diethylcarbamazine [DEC]) is based on 17 studies conducted in Sri Lanka, India, Haiti, Ghana, Tanzania, Kenya, Ecuador, the Philippines, Gabon, Papua New Guinea, and Bangladesh. The total data set comprises 90635 subject exposures and includes individuals of all ages and both genders. Results are presented for hospital-based studies, laboratory studies, active surveillance of microfilaria-positive and microfilaria-negative individuals, and passive monitoring in both community-based studies and mass treatment programmes of individuals treated with albendazole (n=1538), ivermectin (9822), DEC (576), albendazole+ivermectin (7470), albendazole+DEC (69020), or placebo (1144). The most rigorous monitoring, which includes haematological and …
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J Horton, C Witt, EA Ottesen, JK Lazdins, DG Addiss… - Parasitology, 2000
