作者
Juliana Maia, Andreia Soares da Silva, Rodrigo Feliciano do Carmo, Taciana Furtado de Mendonça, Luiz Henrique Maciel Griz, Patricia Moura, Francisco Bandeira
发表日期
2016/8/1
期刊
The application of clinical genetics
页码范围
131-136
出版商
Taylor & Francis
简介
Introduction
Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications.
Aims
To examine the associations between vitamin D receptor polymorphisms (FokI and TaqI) and Type 2 diabetes (T2DM) and its associated chronic complications in postmenopausal women.
Methods
This cross-sectional study analyzed 100 postmenopausal women with T2DM (mean age 65.7±7.18 years) and 100 postmenopausal women without diabetes in the control group (mean age 65.1±9.18 years; P=0.1608). We evaluated clinical and metabolic parameters and analyzed TaqI and FokI polymorphisms.
Results
There were no significant differences in genotype and allele frequencies between patients and controls in either of the polymorphisms studied. In the group of patients with …
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J Maia, AS da Silva, RF do Carmo, TF de Mendonça… - The application of clinical genetics, 2016