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Objectives:

To identify medications administered to pediatric patients on extracorporeal membrane oxygenation and to review the available pharmacokinetics and pharmacodynamics literature for the most commonly administered medications.

Design:

Retrospective single-center study.

Setting:

ICUs at Children’s Hospital of Philadelphia.

Patients:

Pediatric patients supported by extracorporeal membrane oxygenation between October 1, 2014, and September 30, 2018.

Interventions:

None.

Measurements and Main Results:

Drug exposure was described according to age group (< 1 mo, 1 mo to< 2 yr, 2 to< 12 yr, and> 12 yr) and ICU (cardiac, neonatal, pediatric). The association of drug exposure with patient’s characteristics was examined using one-way analysis of variance for categorical variables and linear regression for continuous variables. All pharmacokinetics and pharmacodynamics literature for the 50 most …