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In this work the complexation of five NSAIDs with iron (Fe 3+) was studied and the role of these iron complexes in reducing the proliferation of cancer cells was investigated. The stoichiometry and the formation constants of the complexes formed with different NSAIDs were calculated using the conductivity method. The metal-drug ratio for all drugs was 1: 2 and their formation constant values were between 109 to 1014. The antiproliferative activity of the NSAIDs in their free and complex form was assessed using MCF-7 cells. After 72 hours incubation with the free drugs, mefenamic acid and diclofenac sodium showed the strongest antiproliferative effects with IC50 of 70.54±15.29 μM and 108.38±11.28 μM, respectively. Indomethacin, naproxen and meloxicam had moderate to no effect at the concentrations tested. A linear correlation, with r2= 0.876, between the formation constants of NSAIDs-Fe3+ complexes and …