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This study was undertaken to measure the duration of chronic electrocorticography (ECoG) needed to attain stable estimates of the seizure laterality ratio in patients with drug‐resistant bilateral temporal lobe epilepsy (BTLE).

We studied 13 patients with drug‐resistant BTLE who were implanted for at least 1 year with a responsive neurostimulation device (RNS System) that provides chronic ambulatory ECoG. Bootstrap analysis and nonlinear regression were applied to model the relationship between chronic ECoG duration and the probability of capturing at least one seizure. Laterality of electrographic seizures in chronic ECoG was compared with the seizure laterality ratio from Phase 1 scalp video‐electroencephalographic (vEEG) monitoring. The Kaplan–Meier estimator was used to evaluate time to seizure laterality ratio convergence.

Seizure laterality ratios from Phase 1 scalp …