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To measure the duration of chronic electrocorticography (ECoG) needed to attain stable estimates of the seizure laterality ratio in patients with drug-resistant bilateral temporal lobe epilepsy (BTLE).

Temporal lobe epilepsy (TLE) is the most common drug-resistant focal epilepsy amenable to surgical resection. The benefits of surgery for improving seizure control and neuropsychological function in TLE are greatest when a majority of seizures originate from one side. Unilateral temporal resection predicated on the seizure laterality ratio determined by RNS chronic electrocorticography (ECoG) can be highly effective. However, the minimum duration of chronic ECoG before proceeding to resection remains undefined.

We studied 13 patients with drug-resistant BTLE implanted for at least one year with a responsive neurostimulation device (RNS® System) that provides chronic …