作者
Li-Tan Yang, Patricia A Pellikka, Maurice Enriquez-Sarano, Christopher G Scott, Ratnasari Padang, Sunil V Mankad, Hartzell V Schaff, Hector I Michelena
发表日期
2020/1/7
期刊
Journal of the American College of Cardiology
卷号
75
期号
1
页码范围
29-39
出版商
American College of Cardiology Foundation
简介
Background
The prognostic significance of diastolic blood pressure (DBP) and resting heart rate (RHR) in patients with hemodynamically significant aortic regurgitation (AR) is unknown.
Objectives
This study sought to investigate the association of DBP and RHR with all-cause mortality in patients with AR.
Methods
Consecutive patients with ≥ moderate to severe AR were retrospectively identified from 2006 to 2017. The association between all-cause mortality and routinely measured DBP and RHR was examined.
Results
Of 820 patients (age 59 ± 17 years; 82% men) followed for 5.5 ± 3.5 years, 104 died under medical management, and 400 underwent aortic valve surgery (AVS). Age, symptoms, left ventricular ejection fraction (LVEF), LV end-systolic diameter-index (LVESDi), DBP, and RHR were univariable predictors of all-cause mortality (all p ≤ 0.002). When adjusted for demographics, comorbidities, and …
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LT Yang, PA Pellikka, M Enriquez-Sarano, CG Scott… - Journal of the American College of Cardiology, 2020