查看文章

An adenovirus or adenovirus-like particle Which has a modi? ed binding speci? city conferred by a binding moiety. The binding moiety is heterologous to the adenovirus and is incorporated as a fusion protein With the? ber protein. This alloWs the adenovirus or adenovirus-like particle to bind to a target cell Which is not the natural host cell of the virus. The penton? ber is modi? ed by the insertion or, deletion, or substitution of amino acid residues, that disrupt the host-cell binding function so that the adenovirus or adenovirous like particle does not bind the natural host cell.