查看文章

hyperpolarization and relaxation of vascular smooth muscle cells. 13 Importantly, because the production of AA from LA is tightly regulated, 14 wide variations in dietary LA (above minimal essential intakes) do not materially alter tissue AA content. 15 In tracer studies, the extent of conversion of LA to AA is 0.2%. 16

In studies with vascular endothelial cells, omega-6 PUFA had antiinflammatory properties, suppressing the production of adhesion molecules, chemokines, and interleukins, all key mediators of the atherosclerotic process. 17 In human studies, higher plasma levels of omega-6 PUFAs, mainly AA, were associated with decreased plasma levels of serum proinflammatory markers, particularly interleukin-6 and interleukin-1 receptor antagonist, and increased levels of antiinflammatory markers, particularly transforming growth factor-. 18 When healthy volunteers were given 7 times the usual intake of AA (ie, 1.5 …