作者
Françoise Lunel-Fabiani, Wael Mansour, Abdellahi Ould Amar, Mohamed Aye, Frédéric Le Gal, F-Zahra Fall Malick, Lô Baïdy, Ségolène Brichler, Pascal Veillon, Alexandra Ducancelle, Emmanuel Gordien, Michel Rosenheim
发表日期
2013/11/1
期刊
Journal of Infection
卷号
67
期号
5
页码范围
448-457
出版商
WB Saunders
简介
Objectives
Mauritania is a highly endemic region for hepatitis B (HBV) and delta (HDV) viruses. No data are available on HDV's impact on the severity of liver disease in consecutive HBV-infected patients in Africa. This study evaluated the degree of liver fibrosis in a cohort of chronic HBV carriers.
Methods
Three-hundred consecutive HBV-infected Mauritanian patients were checked for HDV infection via the detection of anti-HDV antibodies (Ab) and viral RNA. HBV- vs. HBV/HDV-infected patients were compared by physical examination, biological analyses, and the APRI (aspartate aminotransferase to platelet ratio index) and FibroMeter tests for determination of liver fibrosis.
Results
More than 30% of the patients had anti-HDVAb. Among these, 62.2% were HDV-RNA positive. Co-infected patients were older (>8-years) than HBV-mono-infected patients. They had more liver tests abnormalities and clinical or ultrasound …
学术搜索中的文章
F Lunel-Fabiani, W Mansour, AO Amar, M Aye… - Journal of Infection, 2013