作者
Marcelina Párrizas, Laura Brugnara, Yaiza Esteban, Alba González-Franquesa, Sílvia Canivell, Serafín Murillo, Elizabeth Gordillo-Bastidas, Roser Cussó, Joan A Cadefau, Pablo M García-Roves, Joan-Marc Servitja, Anna Novials
发表日期
2015/3/1
期刊
The journal of clinical endocrinology & metabolism
卷号
100
期号
3
页码范围
E407-E415
出版商
Oxford University Press
简介
Context
Diabetes is frequently diagnosed late, when the development of complications is almost inevitable, decreasing the quality of life of patients. However, early detection of affected individuals would allow the implementation of timely and effective therapies.
Objective
Here we set to describe the profile of circulating microRNAs (miRNAs) in prediabetic patients with the intention of identifying novel diagnostic and therapeutic tools.
Design
We used real-time RT-PCR to measure the abundance of 176 miRNAs in serum of a cohort of 92 control and prediabetic individuals with either impaired fasting glucose or impaired glucose tolerance, as well as newly diagnosed diabetic patients. We validated the results in a second cohort of control and prediabetic subjects undergoing a therapeutic exercise intervention, as well as in a mouse model of glucose intolerance …
学术搜索中的文章
M Párrizas, L Brugnara, Y Esteban… - The journal of clinical endocrinology & metabolism, 2015