作者
Vancheswaran Gopalakrishnan, Christine N Spencer, Luigi Nezi, Alexandre Reuben, Miles C Andrews, Tatiana V Karpinets, PA Prieto, D Vicente, Karen Hoffman, Spencer Christopher Wei, AP Cogdill, L Zhao, CW Hudgens, DS Hutchinson, T Manzo, M Petaccia de Macedo, T Cotechini, T Kumar, WS Chen, SM Reddy, R Szczepaniak Sloane, J Galloway-Pena, H Jiang, PL Chen, EJ Shpall, K Rezvani, AM Alousi, RF Chemaly, S Shelburne, LM Vence, PC Okhuysen, VB Jensen, AG Swennes, F McAllister, E Marcelo Riquelme Sanchez, Y Zhang, Emmanuelle Le Chatelier, L Zitvogel, Nicolas Pons, JL Austin-Breneman, LE Haydu, EM Burton, JM Gardner, E Sirmans, J Hu, AJ Lazar, T Tsujikawa, A Diab, H Tawbi, IC Glitza, WJ Hwu, SP Patel, SE Woodman, RN Amaria, MA Davies, JE Gershenwald, P Hwu, JE Lee, J Zhang, LM Coussens, ZA Cooper, PA Futreal, CR Daniel, NJ Ajami, JF Petrosino, MT Tetzlaff, Pradeep Sharma, JP Allison, RR Jenq, JA29097493 Wargo
发表日期
2018/1/5
期刊
Science
卷号
359
期号
6371
页码范围
97-103
出版商
American Association for the Advancement of Science
简介
Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. Here we examined the oral and gut microbiome of melanoma patients undergoing anti–programmed cell death 1 protein (PD-1) immunotherapy (n = 112). Significant differences were observed in the diversity and composition of the patient gut microbiome of responders versus nonresponders. Analysis of patient fecal microbiome samples (n = 43, 30 responders, 13 nonresponders) showed significantly higher alpha diversity (P < 0.01) and relative abundance of bacteria of the Ruminococcaceae family (P < 0.01) in responding patients. Metagenomic studies revealed functional differences in gut bacteria in responders, including enrichment of anabolic pathways. Immune profiling suggested enhanced systemic and …
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V Gopalakrishnan, CN Spencer, L Nezi, A Reuben… - Science, 2018