查看文章

Abstract Purpose Myelin Water Fraction (MWF) mapping can be achieved by fitting multi-gradient recalled echo (MGRE) magnitude images with a three-component model or a pseudo-continuous T 2∗ distribution. Recent findings of compartment-specific orientation-dependent magnetic susceptibility shifts have spurred the inclusion of frequency offset (Δ f) terms in the fitting models. In this work, we performed simulations to assess the impact of Δ f's on the MWF, derived from three different fitting models, at two field strengths. Theory and methods White matter MGRE signals were simulated using the Hollow Cylinder Fiber Model at 3 and 7 T, for a range of fiber orientations (θ), and analyzed using: 1) a multi-component T 2∗ signal magnitude model (MCM T 2∗); 2) a three-component T 2∗ signal magnitude model (3CM T 2∗); and, 3) a three-component complex T 2∗ signal model (3CC T 2∗). Results At 3 T, MCM T 2 …