作者
Koichi Fukunaga, Payal Kohli, Caroline Bonnans, Laura E Fredenburgh, Bruce D Levy
发表日期
2005/4/15
期刊
The Journal of Immunology
卷号
174
期号
8
页码范围
5033-5039
出版商
American Association of Immunologists
简介
Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy. In its early exudative phase, neutrophil activation and accumulation in the lung lead to hypoxemia, widespread tissue damage, and respiratory failure. In clinical trials, inhibition of proinflammatory mediators has not proven effective. In this study, we pursued a new investigative strategy that emphasizes mediators promoting resolution from lung injury. A new spontaneously resolving experimental murine model of ALI from acid aspiration was developed to identify endogenous proresolving mechanisms. ALI increased cyclooxygenase 2 (COX-2) expression in murine lung. Selective pharmacologic inhibition or gene disruption of COX-2 blocked resolution of ALI. COX-2-derived products increased levels of the proresolving lipid mediators lipoxin A 4 (LXA 4) and, in the presence of aspirin, 15-epi-LXA 4. Both LXA 4 and 15-epi-LXA 4 …
引用总数
学术搜索中的文章
K Fukunaga, P Kohli, C Bonnans, LE Fredenburgh… - The Journal of Immunology, 2005