作者
Payal Kohli, Marc P Bonaca, Rahul Kakkar, Anastacia Y Kudinova, Benjamin M Scirica, Marc S Sabatine, Sabina A Murphy, Eugene Braunwald, Richard T Lee, David A Morrow
发表日期
2012/1/1
期刊
Clinical chemistry
卷号
58
期号
1
页码范围
257-266
出版商
Oxford University Press
简介
OBJECTIVE
We investigated the prognostic performance of ST2 with respect to cardiovascular death (CVD) and heart failure (HF) in patients with non–ST-elevation acute coronary syndrome (NSTE-ACS) in a large multinational trial.
BACKGROUND
Myocytes that are subjected to mechanical stress secrete ST2, a soluble interleukin-1 receptor family member that is associated with HF after STE-ACS.
METHODS
We measured ST2 with a high-sensitivity assay in all available baseline samples (N = 4426) in patients enrolled in the Metabolic Efficiency With Ranolazine for Less Ischemia in the Non–ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36), a placebo-controlled trial of ranolazine in NSTE-ACS. All events, including cardiovascular death and new or worsening HF, were adjudicated by an independent …
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P Kohli, MP Bonaca, R Kakkar, AY Kudinova… - Clinical chemistry, 2012