作者
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Rory Durcan, Gemma Roberts, Joanna Ciafone, Sally AH Barker, Michael Firbank, Ian G McKeith, Alan J Thomas
发表日期
2021/6/1
期刊
Neurology
卷号
96
期号
22
页码范围
e2685-e2693
出版商
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
简介
Objective
To determine whether mild cognitive impairment with Lewy bodies or mild cognitive impairment with Alzheimer disease differ in their rates of clinical progression to dementia, we undertook longitudinal observation of mild cognitive impairment cases with detailed clinical assessment of Lewy body diagnostic characteristics.
Methods
Two prospective longitudinal cohorts including 111 individuals ≥60 years of age with mild cognitive impairment were assessed annually to track cognitive and clinical progression, including the presence or absence of core clinical features and proposed biomarkers of dementia with Lewy bodies. Multistate modeling was used to assess the associations of diagnostic characteristics of dementia with Lewy bodies with clinical progression from mild cognitive impairment to dementia, with death as a competing outcome.
Results
After a mean follow-up of 2.2 years (range 1–6.7 years …
学术搜索中的文章
CA Hamilton, FE Matthews, PC Donaghy, JP Taylor… - Neurology, 2021
