作者
Gemma Roberts, Paul C Donaghy, Sarah Lawley, Joanna Ciafone, Calum A Hamilton, Sean J Colloby, Michael J Firbank, Louise Allan, Nicola Barnett, Sally Barker, Kim Howe, Tamir Ali, George S Petrides, Jim Lloyd, John-Paul Taylor, John O’Brien, Alan J Thomas
发表日期
2021/4/21
期刊
Neurology
出版商
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
简介
Objective
To provide evidence that cardiac I-123-metaiodobenzylguanidine sympathetic innervation imaging (MIBG) scintigraphy differentiates probable mild cognitive impairment with Lewy bodies (MCI-LB) from mild cognitive impairment due to Alzheimer disease (MCI-AD), we scanned patients with MCI and obtained consensus clinical diagnoses of their MCI subtype. We also performed baseline FP-CIT scans to compare the accuracy of MIBG and FP-CIT.
Methods
We conducted a prospective cohort study into the accuracy of cardiac MIBG scintigraphy in the diagnosis of MCI-LB. Follow-up clinical assessment was used to diagnose MCI-AD (no core features of MCI-LB and normal FP-CIT), probable MCI-LB (2 or more core features, or 1 core feature with abnormal FP-CIT), or possible MCI-LB (1 core feature or abnormal FP-CIT). For the comparison between MIBG and FP-CIT, only core clinical features were used for …
学术搜索中的文章
G Roberts, R Durcan, PC Donaghy, S Lawley… - Neurology, 2021
