作者
Calum A Hamilton, Julia Schumacher, Fiona Matthews, John-Paul Taylor, Louise Allan, Nicola Barnett, Ruth A Cromarty, Paul C Donaghy, Rory Durcan, Michael Firbank, Sarah Lawley, John O'Brien, Gemma Roberts, Alan J Thomas
发表日期
2021/8/18
出版商
Cambridge University Press
简介
Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed …
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